Approximately 50 million adults in the U.S. experienced a mental illness in 2019Mental Health America
Neural plasticity: rewiring connections
In a healthy functioning brain, neurons respond to external experiences by modifying existing connections or creating new ones.
There is increasing evidence that depression is caused by impaired neural plasticity in specific circuits and regions of the brain associated with mood and cognition.
Our goal is to leverage our understanding of neural plasticity to develop new treatment options for CNS disorders, including MDD. Using this rationale, we hypothesize that REL-1017 preferentially blocks hyperactive NMDAR channels that are associated with MDD. REL-1017 has the potential to provide patients with rapid relief by restoring physiological neural plasticity, which would improve symptoms and be potentially curative.